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July 4th, 2009

Oncologists Hold Advanced Options in Treatment for Mesothelioma, Even if Prognosis Looks Desperate

Doctors who specialize in cancer treatment decide what type of treatment to go with for a patient. There are numerous options. There is no regular treatment course for peritoneal mesothelioma cancer patients. This is due to the cancers high mortality rate, rareness, low treatment success rate, and small number of studies to provide meaningful statistics.

Mesothelioma patients have historically had a bleak outlook, but doctors have recently made progress. Traditional treatments for cancer are surgery (removing the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) There are problems with all three. Patients with mesothelioma have not responded well to traditional radiation therapy. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

Surgery takes out the mesothelial cancerous tissue around the tumor. It is a grueling surgery with unknown benefits to patients. The usual chemotherapy cocktails effective on other cancers are not effective on mesothelioma, and combinations of chemotherapy agents have been tried, but without much success. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.

Many advanced techniques in cancer treatment are tried on mesothelioma patients because of its high fatality rate. These techniques include a biologic therapy called the agent interleukin 2 and anti-angiogenesis drugs like thalidomide. A new drug that has shown results in improving survival is pemetrexed (brand name Alimta).

Considered by oncologists is where the tumor is located, what stage the mesothelioma is in, and the age and health of the patient. Theres also photodynamic therapy and gene therapy ” two far-out new ways of attacking cancer. Mesothelioma patients sometimes become involved in clinical trials in this area, and see benefits.

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